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M9480548.TXT
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1994-08-20
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Document 0548
DOCN M9480548
TI In utero diagnosis of congenital infections by direct fetal sampling.
DT 9410
AU Valente P; Sever JL; Laboratory of Central Nervous System Studies,
NINDS, NIH,; Bethesda, MD 20892.
SO Isr J Med Sci. 1994 May-Jun;30(5-6):414-20. Unique Identifier : AIDSLINE
MED/94307927
AB Counseling for infections during pregnancy has traditionally focused on
the clinical and laboratory findings of infection in the mother and the
estimated risk of fetal damage associated with possible transmission of
infection to the child. Now, with the use of techniques for fetal
sampling, it is possible to diagnose infections of the fetus in utero
and to correlate that information with the occurrence of fetal damage.
The techniques that are available for sampling include amniocentesis,
cordocentesis and chorionic villus sampling. The laboratory tests
include: a) isolation of the organism in appropriate laboratory systems;
b) detection of the DNA or RNA of the organism directly or with
amplification with techniques such as PCR; c) detection of the organism
by fluorescence or in situ hybridization; and d) identification of IgM
or IgA fetal antibody to the organism by ELISA or similar methods. In
utero infections can be documented for agents such as rubella,
cytomegalovirus, parvovirus, Toxoplasma gondii and human
immunodeficiency virus type 1. Further information is needed concerning
the sensitivities and specificities of these methods for identifying
fetal infection and predicting fetal damage.
DE Amniocentesis/METHODS Animal Chorionic Villi Sampling/METHODS
Cordocentesis/METHODS Cytomegalovirus Infections/CONGENITAL/DIAGNOSIS
Female Fetal Diseases/*DIAGNOSIS Human HIV
Infections/CONGENITAL/DIAGNOSIS HIV-1 Parvoviridae
Infections/CONGENITAL/DIAGNOSIS Pregnancy *Pregnancy Complications,
Infectious Pregnancy Complications, Parasitic/DIAGNOSIS Prenatal
Diagnosis/*METHODS Rubella/CONGENITAL/DIAGNOSIS Toxoplasmosis,
Congenital/DIAGNOSIS JOURNAL ARTICLE REVIEW REVIEW, ACADEMIC
SOURCE: National Library of Medicine. NOTICE: This material may be
protected by Copyright Law (Title 17, U.S.Code).